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21/04/2020 – AI3SD Winter Seminar Series: Targets

April 21 @ 2:00 pm - 4:45 pm

Free

Eventbrite Link: Coming Soon

Description:
This seminar forms part of the AI3SD Online Seminar Series that will run across the winter (from November 2020 to April 2021). This seminar will be run via zoom, when you register on Eventbrite you will receive a zoom registration email alongside your standard Eventbrite registration email. Where speakers have given permission to be recorded, their talks will be made available on our AI3SD YouTube Channel. The theme for this seminar is Targets.

Agenda

  • 14:00-14:45: Using convolutional neural networks to enable neoantigen load as a biomarker of cancer immunotherapyDr Felicia Ng (AstraZeneca)
  • 14:45-15:00: Coffee Break
  • 15:00-15:45: TBC – Dr Nicola Richmond (GlaxoSmithKline)
  • 15:45-16:00: Coffee Break
  • 16:00-16:45: TBC – TBC

Abstracts & Speaker Bios

  • Using convolutional neural networks to enable neoantigen load as a biomarker of cancer immunotherapy – Dr Felicia Ng: Neoantigens act as surrogates for T cell immunoreactivity and have been shown to correlate with patients’ response to immune checkpoint inhibitors (ICI).  Here, we have developed a multi-allele convolutional neural network-based model, MINERVA, for predicting HLA class I (HLA-I) presentation of tumor antigenic peptides using transfer learning with immunopeptidome data from cancer patients.  We show that MINERVA recapitulates physicochemical properties of naturally presented peptides that are relevant to tumor biology and is more sensitive to tumor-derived HLA presented peptides than existing algorithms. Without a priori knowledge provided to MINERVA, the model was able to learn the determinants of peptide-HLA presentation and we utilized the learnt features to understand the impact of mutations on neoantigen presentation.  Furthermore, we show that the diversity of tumor peptides being presented by a pair of alleles are significantly correlated with HLA sequence divergence.  In conclusion, MINERVA is an open source software that can greatly facilitate tumor neoantigen discovery and guide cancer immunotherapies.
    Bio: Coming Soon.
  • TBC – Dr Nicola Richmond: Abstract Coming soon.
    Bio: Coming Soon.
  • TBC – TBC: Abstract Coming soon.
    Bio: Coming Soon.

Details

Date:
April 21
Time:
2:00 pm - 4:45 pm
Cost:
Free
Event Categories:
,
Event Tags:
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Venue

Online Event

Organiser

AI3SD
Email:
info@ai3sd.org
Website:
www.ai3sd.org